N eural dynamics underlying brain thalamic oscillations investigated with computational models
نویسندگان
چکیده
This thesis is concerned with normal and pathological oscillations generated in thalamocortical neuronal network. By means of anatomically and physiologically based computational models we attempt to provide insight into phenomena such as event-related dynamics of alpha band rhythms and spontaneous generation of absence seizures. We present novel hypothesis regarding the neurophysiological substrates and functional significance of antagonistic behavior of alpha band rhythms in neighboring cortical areas during performance of attentional tasks. We also identify cellular and network properties that may condition epileptic oscillations and the transition from normal to pathological state. Furthermore we demonstrate annihilation of pathological rhythm by external stimulation, which may contribute to development of seizures suppression.
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